21 Jun 2018 --- Not only do citric acid and spicy 6-gingerol from ginger add special flavors to food and beverages; both substances also stimulate the molecular defenses in human saliva, researchers from the Technical University of Munich (TUM) and the Leibniz-Institute for Food Systems Biology have found. The findings demonstrate the potential of flavor substances to have properties that go beyond the sensory.
The researchers sought to discover the effect of food and drink on the composition of saliva.
Human saliva is a complex, watery mixture made up of vastly different components. In addition to mucosal and immune cells, it contains a large number of molecules that perform a wide variety of biological functions. Not only does saliva play an important role in dietary intake, but it is also crucial to maintaining the health of one’s teeth, gums and oral mucosa. At the same time, it also represents the first defense against external pathogens.
The team of scientists led by Professor Thomas Hofmann, head of the Leibniz-Institute for Food Systems Biology at TUM, studied the influence of the following flavors on the composition of human saliva: citric acid (sour), the sweetener aspartame (sweet), iso-alpha acids (bitter), the flavor enhancer monosodium glutamate (umami), table salt (salty), 6-gingerol (spicy), and the substances contained in Sichuan pepper – hydroxy-alpha-sanshool (tingling) and hydroxy-beta-sanshool (numbing).
It was found that all the substances under investigation modulate the protein composition of saliva to a greater or lesser extent. Analyses of the biological function of the salivary proteins affected by modulation also showed that the changes triggered by citric acid and 6-gingerol activate the molecular defense system in saliva.
For example, 6-gingerol increased the activity of an enzyme that converts the thiocyanate contained in saliva into hypothiocyanite, approximately tripling the amount of the antimicrobial and fungicidal hypothiocyanite in saliva. The changes triggered by citric acid, on the other hand, caused lysozyme levels in saliva to increase tenfold.
Studies on bacterial cultures have shown for the first time that this increase is sufficient to almost completely prevent the growth of Gram-positive bacteria. Lysozyme acts against this type of bacteria by destroying their cell walls.
“Our new findings show that flavoring substances already display biological effects in the oral cavity that go far beyond their known sensory properties,” says Professor Hofmann from the Department of Food Chemistry and Molecular Sensory Science at TUM. The food chemist explains that one of the goals of food systems biology is to further investigate these using the latest analytical methods. In his opinion, this is the only way to find new approaches for the long-term production of food whose ingredient and function profiles are aligned with the health and sensory needs of consumers.
13 Jul 2018 –
Sensient Technologies Corporation, a global ...
04 Jul 2018 –
The demand for natural, sustainable and ...
04 Jul 2018 –
Dean Foods Company has increased its ownership ...
21 Jun 2018 –
General Mills' venture arm, 301 Inc., is ...
11 May 2018 –
US researchers examining how to manipulate gut ...