14 Feb 2018 --- A diet rich in saturated fat, such as palm oil, and sugar not only leads to obesity, but it also creates inflammation in the nucleus accumbens, a part of the brain that controls mood and the feeling of reward. This inflammation can lead to depressive, anxious and compulsive behavior and disrupt metabolism, according to a study from the University of Montreal Hospital Research Centre (CRCHUM). The discovery illustrates the vicious circle experienced by people with obesity caused by a diet rich in sugar and saturated fat, with their diet leading to negative emotions, which can stimulate the quest for more comfort through food.
Published in the journal Molecular Metabolism, the study provides new evidence confirming the harmful effect of saturated fat on health. Although this study was conducted with animals, the researchers note that it is believed that the mechanism that occurs in the nucleus accumbens of humans is similar.
“The depressive, anxious and compulsive behaviors and the metabolic changes observed with a diet rich in sugar and saturated fat were not observed with a diet rich in sugar and monounsaturated fat, the type of fat found in olive oil,” says Stéphanie Fulton, a CRCHUM researcher and professor in the Department of Nutrition of Université de Montréal’s Faculty of Medicine.
The metabolic changes observed with the diet high in saturated fat, such as hyperinsulinemia and glucose intolerance, are associated with pre-diabetes.
Fulton and her team of researchers worked with two groups of mice fed a diet containing the same number of calories every day, 50 percent of which were from fat. One of the groups was fed a saturated-fat diet, while the other received monounsaturated fat. The third group of mice was fed a low-fat diet.
“The animals with the diet rich in saturated fat voluntarily ate more grams of food, and therefore, more calories,” Léa Décarie-Spain, the study’s first author and a Ph.D. student in the laboratories of Fulton , explains.
“It took only 12 weeks for the diet rich in saturated fat to cause obesity, anxiodepressive behaviors and the metabolic changes associated with prediabetes,” she says.
Many studies conducted on humans have shown that a Mediterranean diet low in saturated fat has a protective effect against depression. In this study, the researchers were able to identify the neuronal mechanisms that link obesity to depression. Anxiodepressive behaviors were found to result from inflammation observed in the nucleus accumbens. A genetic manipulation made it possible to inhibit the molecule that plays a key role in spreading the inflammation to that part of the brain.
“This manipulation succeeded in protecting the mice with a diet rich in saturated fat from inflammation; consequently, the signs of depression and anxiety and the compulsive behaviors associated with sugar disappeared,” explains Décarie-Spain.
These advances pave the way for further research into an anti-inflammatory genetic intervention in the nucleus accumbens that could inhibit depression caused by inflammation.
“We hope that this study will help educate people about the importance of diet, not only because of the cardiovascular diseases and cancers associated with obesity, but also because of the neurological and psychiatric problems that are increasingly linked to obesity,” said Fulton. “We also hope that our results will put pressure on the food industry to replace these types of fat with monounsaturated fats.”
A few cookies or a hamburger from time to time won’t bring on a case of depression, the researchers cautioned.
“We should simply avoid eating such foods on a regular basis in order to keep our metabolism healthy and free of inflammation,” said Décarie-Spain. “It’s a question of moderation.”