Digestive Health

Gut appeal: Healthy microbiome thanks to food processing waste

15 Feb 2019 --- New research from Maastricht University (UM) has uncovered a novel use for waste from the food processing industry: boosting the microbiome. Using the TNO in vitro model of the colon (TIM-2), research by Carlota Bussolo de Souza has shown that fermenting fiber from fruit and vegetable peel can help improve the gut flora of people with obesity.

Gut bacteria and depression: “Compelling” further support to the “gut brain axis” notion

14 Feb 2019 --- Researchers have established a correlation between depression and a group of neurotransmitter-producing bacteria found in the human gut, further expanding clinical evidence of the gut-brain axis. Interestingly, an inverse relationship between specific gut bacteria and brain activity in areas connected to depression were identified in the animal study. Published in Nature Microbiology, the findings could lead to the development of bacterial therapeutics for depression, including a growing role for probiotics, but significant work is first required, the researchers note.

Mapping the human gut: Researchers identify 2,000 gut microbes

12 Feb 2019 --- Researchers at the European Molecular Biology Laboratory's (EMBL) European Bioinformatics Institute (EBI) and the Wellcome Sanger Institute have identified almost 2,000 gut bacterial species, using a range of computational methods. Since the findings are mostly based on European and Northern American samples the researchers are highlighting the need for more data from other regions of the world.

A game-changer in probiotics? Microbiome discovery could stimulate innovation

05 Feb 2019 --- Scientists are one step closer to uncovering how the gut microbiome affects our health, after isolating more than 100 previously unknown species of bacteria from healthy people’s intestines. The involved researchers have created what they say is the most “comprehensive public database of human health-associated intestinal bacteria to date.” It could provide a wealth of information on treating different disorders, as well as a diverse range of potential probiotics.

Evolutionary gut cell mechanism found to slow down metabolism and increase CVD risk

04 Feb 2019 --- Specific cells in the guts of mice slow down metabolism and can eventually contribute to obesity, diabetes, hypertension and atherosclerosis. These findings, published in Nature, could have important implications for the prevention and treatment of these kinds of metabolic diseases in humans. The energy-saving mechanism evolved over millions of years to provide an advantage to organisms when food was scarce, the researchers note, but it may now be backfiring as food is so abundant.

CRISPR/Cas9 holds promise for producing wheat safe for celiacs, researchers say

29 Jan 2019 --- Modern biotechnology can be used to entirely remove gluten from the wheat genome or target and remove “toxic” epitopes from the gluten protein. This means that the gluten retains its unique baking characteristics, but does not trigger an autoimmune response in celiacs, according to University of Wageningen researchers. Celiac disease is an autoimmune disorder, whereby the consumption of gluten triggers an immune system response in the the gut. The only intervention currently available is a strict, lifelong gluten-free diet, which can be challenging to follow. However, the use of gene editing tool CRISPR/Cas9 could present future opportunities, say the researchers.

Microbiome medicine: “Unlocking” the secrets behind fecal transplant “super donors”

22 Jan 2019 --- Fecal transplants could be used to treat intestinal disorders such as inflammatory bowel disease, and perhaps even help prevent Alzheimer's and cancer, if the secrets of the gut-rejuvenating properties of “super donors” could be unlocked, say Australian researchers. The researchers reviewed fecal transplantation trials for clues to the origin of the “super-donor” phenomenon, yet concluded that further research is needed to uncover the role of external factors, such as diet and naturally occurring gut diversity.

Microbiome analysis company Bio-Me inks biomarker deal to boost major Norwegian health study

21 Jan 2019 --- Bio-Me, a start-up specializing in rapid gut microbiome analysis, has entered into an agreement with an unnamed “top” consumer healthcare company associated with the large-scale Nord-Trøndelag Health Study (HUNT). The HUNT 4 study is governed by the Norwegian University of Science and Technology (NTNU) and is reportedly one of the most extensive health studies ever performed. The partnership will see Bio-Me using its Precision Microbiome Profiling (PMP) platform and the HUNT BioBank to identify gut microbiome biomarkers for specific health conditions.

Synbiotics in the mainstream? Danone boosts Activia Probiotic Dailies line with prebiotic fibers

10 Jan 2019 --- Food and beverage company Danone is adding two new flavors to its popular Dannon Activia Probiotic Dailies line, launched last year in the US; this time fortified with prebiotic fibers. Served up in a convenient “daily shot” format, the yogurt-based dose promises to deliver billions of live and active probiotics, and on-trend flavors: Lemon & Ginger and Honey & Ginger. The addition of prebiotic fibers to the line is a firm nod towards fiber, as although the ingredient on everyone's lips in 2018 may have been protein, fiber has been pegged to be huge in 2019.

Flying Embers and Reyes Beverage Group launch adaptogenic organic alcoholic kombucha line of beverages

20 Dec 2018 --- US beverage brand Flying Embers is partnering with beer distributor Reyes Beverage Group to launch a fermented alcoholic beverage line fortified with adaptogenic ingredients. The drink is fermented with a base of ginger, turmeric, astragalus and the increasingly popular adaptogen ashwagandha.

Expanding the gut-brain axis: Do probiotics hold potential as treatment for bipolar disorder?

20 Dec 2018 --- Probiotics have been flagged as a potential avenue of treatment to alleviate bipolar and other psychiatric mood disorders, a Baltimore Sheppard Pratt Health System study has found. Published in Bipolar Disorders, the research showed that a probiotic supplement reduced inflammation, which is known to exacerbate bipolar disorder, in the gut of participants hospitalized for mania. Probiotic organisms are non-pathogenic bacteria that, when present in the gut flora, may improve the overall health of the host.

GutGuide: Affordable gut testing for personalized nutrition

11 Dec 2018 --- With the rise of personalized nutrition and the growing interest in gut health has come an array of personalized gut testing services. In this space, Finnish company GutGuide is seeking to offer reasonably-priced, patient-specific treatment and supplementation to a variety of afflictions connected to the gut, based on the company’s research into oral and gut microbiota. The role for a good functioning microbiota in skin health will be the next platform for the technology.

New research links gut microbiome to ethnicity

07 Dec 2018 --- The gut microbiome is closely linked to overall health and may vary according to ethnicity, joint research between Vanderbilt University, Tennessee, and the University of Minnesota, US, has found. However, the researchers point out that although foods and supplements that target the microbiome are currently gaining popularity, more research is needed to pinpoint what exactly constitutes a healthy gut microbiome.

Diana eyes synbiotic opportunities: Symrise Nutrition Division to assess polyphenol and probiotic synergies

04 Dec 2018 --- Diana, the Nutrition Division of Symrise, is eyeing the potential of fusing fruit and vegetable polyphenols with probiotic strains from the company’s Probi business for the creation of synbiotic ingredients. One of the key platforms for a new research project will be assessing the potential for optimal gut health products that combine Probi strains such as LP299V with prebiotics.

HiE 2018: Carbery to enter digestive health market with fermented protein ingredient launch

27 Nov 2018 --- Carbery will be unveiling a new ingredient range at Health Ingredients Europe 2018 (HiE), beginning today in Germany, which targets the digestive health and active consumer segments. By combining the two trends of fermentation and protein, the new dairy ingredients, coined Bifipro, deliver a unique combination of high-quality protein with prebiotic promoting properties.

Personalized nutrition: Carbiotix sets out to mainstream gut health monitoring

26 Nov 2018 --- Personalized nutrition has been high on the industry agenda for a while. But despite the popularity of the phrase, there is still ample space for development in terms of bringing personalized options to a wider consumer base in an affordable and scientifically-sound way. In this space, health solutions company Carbiotix is paving the way by offering low cost, personalized gut testing services (starting at €19 a month) and personalized soluble fiber supplements.

Symprove multi-strain supplement linked to re-balancing of gut microbiome

20 Nov 2018 --- “Good” bacteria in the live probiotic Symprove can successfully reach and colonize the gut, where they can modify existing gut flora, according to new research published in the International Journal of Pharmaceutics. Researchers also noted that these bacteria are capable of modifying the immune response in the human body.

Navigating the digestive health space: Probiotic strain specificity and microbiome key to future NPD

16 Nov 2018 --- Emerging science linking a healthy microbiome to nearly every facet of health, as well as the ongoing media reporting on probiotics, have helped drive consumer interest in gut health. This growing area offers a wealth of opportunities to formulators, but due to regulatory demands and increasing consumer scrutiny, a clear view of how to navigate this space is vital.

Kellogg’s debuts gut-boosting cereal with prebiotics, probiotics and fiber

15 Nov 2018 --- Kellogg’s has launched a “3-in-1” cereal aimed at making digestive wellness support easily accessible in food. The new wellness brand HI! Happy Inside delivers prebiotics, probiotics and fiber in an all-in-one cereal. The launch comes at a time when interest in digestive health seems to only continue to grow.

Cranberries found to reduce negative effects of animal-based diet on gut health

15 Nov 2018 --- A Cranberry Institute and USDA-funded study into the potential protective effects of cranberries on the gut microbiome has found that adding cranberries to a meat-based diet can reduce the rise in secondary gut bile acids that have been associated with colon and GI cancer. The feeding trial – published in The Journal of Nutritional Biochemistry – found that the addition of whole cranberry powder to this common diet lessened potentially carcinogenic secondary bile acids and blunted the decline in beneficial short-chain fatty acids (SCFA) in the gastrointestinal (GI) tract.

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